SIRT1 ACTIVATED BY AROS SENSITIZES GLIOMA CELLS TO FERROPTOSIS VIA INDUCTION OF NAD+ DEPLETION-DEPENDENT ACTIVATION OF ATF3

SIRT1 activated by AROS sensitizes glioma cells to ferroptosis via induction of NAD+ depletion-dependent activation of ATF3

Ferroptosis is a type of programmed cell death resulting from iron overload-dependent lipid peroxidation, and could be promoted by activating transcription factor 3 (ATF3).SIRT1 is an enzyme accounting for removing acetylated lysine residues from target proteins by consuming NAD+, but its role remains elusive in ferroptosis and activating ATF3.In t

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Tooth mineralization and histology patterns in extinct and extant snaggletooth sharks, Hemipristis (Carcharhiniformes, Hemigaleidae)-Evolutionary significance or ecological adaptation?

Shark jaws exhibit teeth that are arranged into distinct series and files and display great Divertor Valve diversities in shapes and structures, which not only is related to their function (grasping, cutting, crushing) during feeding, but also bear a strong phylogenetic signal.So far, most research on the relationship between shark teeth and feedin

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